Prednisolone and prednisone neo-formation in bovine urine after sampling

Prednisolone and prednisone neo-formation in bovine urine after sampling.

The rise in the frequency of detecting prednisolone in bovine urine from northern Italy has come into focus of attention in recent years. The possibility that neo-formation of prednisolone or that prednisone may occur in urine after collection of samples was therefore investigated. Cow urine collected for official routine controls in Lombardy containing more than 80 ng/ml cortisol, and predniso...

Determination of Cortisol, Cortisone, Prednisolone and Prednisone in Bovine Urine by Liquid Chromatography-electrospray Ionisation Single Quadrupole Mass Spectrometry

Prednisone and prednisolone in ocular disease.

The introduction of cortisone and hy­ drocortisone with their attendant success in ocular therapy has inevitably sparked a search for better analogs of these steroids. The chief aim of these investigations is the development of a compound that has the maximal curative power and minimal ability to produce undesirable side effects. A host of compounds has been produced during this hunt. The lates...

A field survey on the presence of prednisolone and prednisone in urine samples from untreated cows.

Prednisolone is a synthetic glucocorticoid widely employed in bovine clinical practice that may also be used illegally as a growth promoter. Recent in vitro and in vivo studies lend support to the hypothesis that prednisolone could be synthesised from cortisol in untreated cattle subjected to stressful events. To verify such a hypothesis, a field survey was conducted on urine samples collected ...

Prednisone and Prednisolone in the Treatment of Rheumatoid Arthritis

EXPERIENCE of the limitations of cortisone and hydrocortisone as therapeutic agents in the management of patients with rheumatoid arthritis has led to a search for newer and more potent compounds with fewer undesirable side effects. With the knowledge that the physiological properties of the adrenal steroids can be modified by relatively minor adjustments of their structural formula, a number o...